Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development.

  title={Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development.},
  author={Michael S Rafii and Hiroki Hagiwara and Mary Lynn Mercado and Neung S Seo and Tianshun Xu and Tracey A Dugan and Rick T. Owens and M. D. Hook and David James McQuillan and Marian Frances Young and Justin R. Fallon},
  journal={Journal of cellular physiology},
  volume={209 2},
The dystrophin-associated protein complex (DAPC), which links the cytoskeleton to the extracellular matrix, is essential for muscle cell survival, and is defective in a wide range of muscular dystrophies. The DAPC contains two transmembrane subcomplexes-the dystroglycans and the sarcoglycans. Although several extracellular binding partners have been identified for the dystroglycans, none have been described for the sarcoglycan subcomplex. Here we show that the small leucine-rich repeat (LRR… CONTINUE READING


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