Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species

@inproceedings{Li2017BigelovinTA,
  title={Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species},
  author={Mingyue Li and Li-hua Song and Grace Gar-Lee Yue and Julia Kin-Ming Lee and Li-mei Zhao and Lin Li and Xunian Zhou and Stephen Kwok-Wing Tsui and Simon Siu-man Ng and Kwok-pui Fung and Ninghua Tan and Clara Bik-San Lau},
  booktitle={Scientific reports},
  year={2017}
}
Colorectal cancer (CRC) is the third most prevalent cancer and the third highest cancer-related mortality in the United States. Bigelovin, a sesquiterpene lactone isolated from Inula helianthus aquatica, has been proven to induce apoptosis and exhibit anti-inflammatory and anti-angiogenic activities. However, the effects of bigelovin on CRC and underlying mechanisms have not been explored. The present study demonstrated that bigelovin exhibited potent anti-tumor activities against CRC in vitro… CONTINUE READING
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