Big interest in heavy drugs

  title={Big interest in heavy drugs},
  author={K. Sanderson},
Pharmaceutical companies are beginning to bet on the idea that simply switching a hydrogen atom with a heavier isotope in a currently approved drug could create a better drug. Encouraged by results from clinical trials, companies are snapping up intellectualproperty rights on many of the modified drugs. On 16 March, for example, Concert Pharmaceuticals of Lexington, Massachusetts, reported results of a phase I clinical trial for a version of the antidepressant paroxetine, sold as Seroxat by… Expand
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  • Journal of analytical toxicology
  • 2009
The toxicology community should be aware that pharmaceutical companies are developing deuterated analogues of therapeutic agents, purported to have improved margins of safety and reduced potentialExpand
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Synopsis of some recent tactical application of bioisosteres in drug design.
  • N. Meanwell
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2011
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DV-127 was synthesized by using three generations of thienopyridine P2Y12 receptor antagonists as research models, using high resolution mass spectrometry, selective deuteration, and 2,7-position replacement groups technologies in order to maximize cardiovascular benefit while minimizing adverse effects on hemostasis and results show that although the dose of DV-127 is greatly reduced, it can achieve similar anticoagulant and antiplatelet effects as clopidogrel. Expand