Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension.

@article{Rubens2001BigEA,
  title={Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension.},
  author={Craig Rubens and Ralph Ewert and Michael Halank and Roland Wensel and Hans D Orzechowski and Heinz Peter Schultheiss and Gert Hoeffken},
  journal={Chest},
  year={2001},
  volume={120 5},
  pages={1562-9}
}
STUDY OBJECTIVES Primary pulmonary hypertension (PPH) is a rare disease of unknown etiology that is characterized by a poor prognosis. This study was undertaken to investigate possible correlations between endothelin (ET)-1 and big ET-1 plasma levels and the severity of PPH. PATIENTS Sixteen consecutive patients with PPH were included. INTERVENTIONS Hemodynamics of patients with PPH were measured by right-heart catheterization, and a 6-min walk test was performed. MEASUREMENTS Plasma… CONTINUE READING

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