Big-data approaches to protein structure prediction

  title={Big-data approaches to protein structure prediction},
  author={Johannes S{\"o}ding},
A protein's structure determines its function. Experimental protein structure determination is cumbersome and costly, which has driven the search for methods that can predict protein structure from sequence information (1). About half of the known proteins are amenable to comparative modeling; that is, an evolutionarily related protein of known structure can be used as a template for modeling the unknown structure. For the remaining proteins, no satisfactory solution had been found. On page 294… CONTINUE READING