Big Bang Tumor Growth and Clonal Evolution.

@article{Sun2018BigBT,
  title={Big Bang Tumor Growth and Clonal Evolution.},
  author={Ruping Sun and Zheng Wen Hu and Christina Curtis},
  journal={Cold Spring Harbor perspectives in medicine},
  year={2018},
  volume={8 5}
}
The advent and application of next-generation sequencing (NGS) technologies to tumor genomes has reinvigorated efforts to understand clonal evolution. Although tumor progression has traditionally been viewed as a gradual stepwise process, recent studies suggest that evolutionary rates in tumors can be variable with periods of punctuated mutational bursts and relative stasis. For example, Big Bang dynamics have been reported, wherein after transformation, growth occurs in the absence of… CONTINUE READING
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