Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors

@article{ebestk2011BifunctionalPC,
  title={Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors},
  author={Jaroslav {\vS}ebest{\'i}k and S{\'e}rgio M. Marques and Pedro Lu{\'i}s Vieira Fal{\'e} and Susana Santos and Daniela Moniz Ardu{\'i}no and Sandra Morais Cardoso and Catarina R. Oliveira and M. Luisa Serralheiro and M. Am{\'e}lia Santos},
  journal={Journal of Enzyme Inhibition and Medicinal Chemistry},
  year={2011},
  volume={26},
  pages={485 - 497}
}
Because of the complex cascade of molecular events that can occur in the brain of an Alzheimer’s disease (AD) patient, the therapy of this neurodegenerative disease seems more likely to be achieved by multifunctional drugs. Herein, a new series of dual-targeting ligands have been developed and in vitro bioevaluated. Their architecture is based on conjugating the acetylcholinesterase inhibition and anti-oxidant properties in one molecular entity. Specifically, a series of naturally occurring… 
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