Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain

@inproceedings{Lagard2017BifunctionalPO,
  title={Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain},
  author={Camille Lagard and Lucie Chevillard and Karel Guillemyn and Patricia Ris{\`e}de and J L Laplanche and Mariana Spetea and Steven Ballet and Bruno M{\'e}garbane},
  booktitle={Pain},
  year={2017}
}
Drugs able to treat both nociceptive and neuropathic pain effectively without major side effects are lacking. We developed a bifunctional peptide-based hybrid (KGNOP1) that structurally combines a mu-opioid receptor agonist (KGOP1) with antinociceptive activity and a weak nociceptin receptor antagonist (KGNOP3) with anti-neuropathic pain activity. We… CONTINUE READING