Bifunctional chelators in the design and application of radiopharmaceuticals for oncological diseases.

@article{Sarko2012BifunctionalCI,
  title={Bifunctional chelators in the design and application of radiopharmaceuticals for oncological diseases.},
  author={Dikran Sarko and Michael Eisenhut and Uwe Haberkorn and Walter Mier},
  journal={Current medicinal chemistry},
  year={2012},
  volume={19 17},
  pages={
          2667-88
        }
}
Radiopharmaceuticals constitute diagnostic and therapeutic tools for both clinical and preclinical applications. They are a blend of a tracer moiety that mediates a site specific accumulation and an effector: a radioisotope whose decay enables either molecular imaging or exhibits cytotoxic effects. Radioactive halogens and lanthanides are the most commonly used isotopes for radiopharmaceuticals. Due to their ready availability and the facile labeling metallic radionuclides offer ideal… CONTINUE READING
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