Biflavonoids of Dacrydium balansae with potent inhibitory activity on dengue 2 NS5 polymerase.

@article{Coulerie2012BiflavonoidsOD,
  title={Biflavonoids of Dacrydium balansae with potent inhibitory activity on dengue 2 NS5 polymerase.},
  author={Paul Coulerie and C{\'e}cilia Eydoux and Edouard Hnawia and Laetitia Stuhl and Alexandre Maciuk and Nicolas Lebouvier and Bruno Canard and Bruno Figad{\`e}re and Jean Claude Guillemot and Mohammed Nour},
  journal={Planta medica},
  year={2012},
  volume={78 7},
  pages={
          672-7
        }
}
In order to find new molecules for antiviral drug design, we screened 102 ethyl acetate extracts from New-Caledonian flora for antiviral activity against the dengue 2 virus RNA-dependant RNA polymerase (DV-NS5 RdRp). The leaf extract of Dacrydium balansae, which strongly inhibited the DV-NS5, was submitted to bioguided fractionation. Four biflavonoids ( 1- 4), three sterols ( 5- 7), and two stilbene derivatives ( 8- 9) were identified and evaluated for their antiviral potential on the DV-NS5… Expand
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