Bifidobacterium longum as an oral delivery system of endostatin for gene therapy on solid liver cancer

@article{Fu2005BifidobacteriumLA,
  title={Bifidobacterium longum as an oral delivery system of endostatin for gene therapy on solid liver cancer},
  author={Geng-feng Fu and Xia Li and Yayi Hou and Yan-Rong Fan and Wenhua Liu and Gen-xing Xu},
  journal={Cancer Gene Therapy},
  year={2005},
  volume={12},
  pages={133-140}
}
To overcome difficulties that hampered widespread application of a specific delivery system in cancer gene therapy and to inhibit the growth of solid liver cancer, we utilized a strain of Bifidobacterium longum as a delivery system to transport an endostatin gene that can inhibit growth of tumor. The B. longum strain with the endostatin gene (B. longum-En) was taken orally by tumor-bearing nude mice through drencher preparation. The results showed that B. longum-En could strongly inhibit the… CONTINUE READING

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