Bifidobacterium longum, a lactic acid-producing intestinal bacterium inhibits colon cancer and modulates the intermediate biomarkers of colon carcinogenesis.

@article{Singh1997BifidobacteriumLA,
  title={Bifidobacterium longum, a lactic acid-producing intestinal bacterium inhibits colon cancer and modulates the intermediate biomarkers of colon carcinogenesis.},
  author={J Singh and Abraham Rivenson and Mamoru Tomita and Seiichi Shimamura and Norio Ishibashi and Bandaru S. Reddy},
  journal={Carcinogenesis},
  year={1997},
  volume={18 4},
  pages={
          833-41
        }
}
The human colon can be described as a complex microbial ecosystem, comprising several hundred bacterial species. Some of these enteric bacteria are beneficial to the host and have been shown to exert antimutagenic and anticarcinogenic properties. We have investigated the colon tumor inhibitory activity of Bifidobacterium longum, a lactic acid-producing enterobacterium. The modifying effects of this lactic culture on colonic mucosal and/or tumor cell proliferation, ODC activity and ras-p21… Expand
Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates the formation of aberrant crypt foci, mucin-depleted foci, and cell proliferation on 1,2-dimethylhydrazine-induced colorectal carcinogenesis in Wistar rats.
TLDR
The dietary intervention of probiotics and PXC significantly protects against the development of CRC in the rat-DMH model and suggests that probiotic LaBb Dahi alone or as an adjunct with P XC may have anti-neoplastic and anti-proliferative activities. Expand
A synbiotic combination of resistant starch and Bifidobacterium lactis facilitates apoptotic deletion of carcinogen-damaged cells in rat colon.
TLDR
It appears likely that ingested RS acts as a metabolic substrate, thus creating the right conditions for B. lactis to exert its proapoptotic action, and this combination facilitates the apoptotic response to DNA damage by a cancer initiator in the colon of rats. Expand
[The role of intestinal microflora and probiotic bacteria in prophylactic and development of colorectal cancer].
TLDR
Research on the role of intestinal microflora in colorectal cancer development is reviewed, wherein it has been clearly revealed that some lactic acid bacteria, especially lactobacilli and bifidobacteria, inhibit initiation and progression of colorective cancer. Expand
Prevention of colon cancer by pre- and probiotics: evidence from laboratory studies.
  • B. Reddy
  • Biology, Medicine
  • The British journal of nutrition
  • 1998
TLDR
Dietary administration of oligofructose and inulin inhibits the formation of preneoplastic lesions in the colon suggesting the potential colon tumour inhibitory properties of chicory fructans. Expand
Lack of inhibitory effects of lactic acid bacteria on 1,2-dimethylhydrazine-induced colon tumors in rats.
  • W. Li, Chong Li
  • Medicine, Biology
  • World journal of gastroenterology
  • 2003
TLDR
It is indicated that lactic acid bacteria lacks inhibitory effects on the progression of colon tumor in 1,2-dimethylhydrazine (DMH)-treated animals, and does not support the hypothesis that alteration of colonic flora may exert an influence on the progress of Colon tumor. Expand
Possible mechanisms by which pro- and prebiotics influence colon carcinogenesis and tumor growth.
  • B. Reddy
  • Biology, Medicine
  • The Journal of nutrition
  • 1999
TLDR
Dietary administration of oligofructose and inulin inhibits the development of ACF in the colon, suggesting the potential colon tumor inhibitory properties of chicory fructans. Expand
Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits
TLDR
The traditional use of bifidobacteria in fermented dairy products and the GRAS status of certain strains attest to their safety, and some strains show high gastrointestinal survival capacity and exhibit probiotic properties in the colon. Expand
Dietary resistant starch and chronic inflammatory bowel diseases
TLDR
Testing the benefit of resistant starch on ulcerative colitis via prebiotic and butyrate effects and the calculation of intestinal short-chain fatty acid absorption confirmed the importance of RS in the therapy of a number of intestinal diseases and the maintenance of health. Expand
Probiotics prevent the development of 1,2-dimethylhydrazine (DMH)-induced colonic tumorigenesis through suppressed colonic mucosa cellular proliferation and increased stimulation of macrophages.
TLDR
The results suggest that dietary consumption of probiotics resulted in a significant inhibition of DMH-induced aberrant crypt foci (ACF) formation in male ICR mice and demonstrate the in vivo chemopreventive efficacy and the immune stimulating mechanisms of dietary probiotics against DMh-induced colonic tumorigenesis. Expand
Selection and characterization of the probiotic potential of some lactic acid bacteria isolated from infant feces
TLDR
The immunomodulatory studies demonstrated that the probiotic culture fractions are modulating the expression of the most important cytokines in the development of the anti-infectious immunity against enteric pathogens, expressed by the stimulation of TNF-alpha and INF-gamma pro-inflammatory cytokines and the inhibition of IL-6 and IL-8 cytokines. Expand
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