Bifidobacterium bifidum BF-1 suppresses Helicobacter pylori-induced genes in human epithelial cells.

@article{Shirasawa2010BifidobacteriumBB,
  title={Bifidobacterium bifidum BF-1 suppresses Helicobacter pylori-induced genes in human epithelial cells.},
  author={Yumi Shirasawa and Harue SHIBAHARA-SONE and Tohru Iino and Fumiyasu Ishikawa},
  journal={Journal of dairy science},
  year={2010},
  volume={93 10},
  pages={4526-34}
}
Helicobacter pylori infection alters gene expression in host cells. Specifically, inflammatory chemokines such as IL-8 are upregulated in the gastric mucosa during H. pylori infection. Although the mechanism by which H. pylori causes inflammation of the gastric mucosa is not yet understood, many studies have suggested that nuclear factor kappa B (NF-κB) plays a key regulatory role in host cells. We have shown that preincubation with Bifidobacterium bifidum strain BF-1, a probiotic strain known… CONTINUE READING