BifA, a cyclic-Di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa PA14.

@article{Kuchma2007BifAAC,
  title={BifA, a cyclic-Di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa PA14.},
  author={Sherry L. Kuchma and Kimberly M. Brothers and Judith H. Merritt and Nicole T. Liberati and Frederick M. Ausubel and George A O'Toole},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 22},
  pages={
          8165-78
        }
}
The intracellular signaling molecule, cyclic-di-GMP (c-di-GMP), has been shown to influence bacterial behaviors, including motility and biofilm formation. We report the identification and characterization of PA4367, a gene involved in regulating surface-associated behaviors in Pseudomonas aeruginosa. The PA4367 gene encodes a protein with an EAL domain, associated with c-di-GMP phosphodiesterase activity, as well as a GGDEF domain, which is associated with a c-di-GMP-synthesizing diguanylate… CONTINUE READING

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