Biexponential fitting of diffusion-ordered NMR data: practicalities and limitations.

Abstract

High resolution diffusion-ordered NMR spectroscopy (HR-DOSY) generally uses monoexponential fitting of the diffusional attenuation of pulsed-field gradient stimulated echo spectra and can, thus, only give proper separation of signals in the diffusion domain where the individual peaks are well-resolved in the spectral domain. In principle, it should be possible to resolve the decays of coincident spectral peaks by multiexponential fitting, but the well-known fundamental difficulties in such a separation are exacerbated by instrumental distortions of the signal decay. The limitations imposed on biexponential fitting by finite signal-to-noise ratio and by the distortion of the theoretical form of the signal attenuation as a result of pulsed-field gradient nonuniformity are explored, and the improvement in DOSY spectra produced using biexponential fitting afforded by compensating for the latter are illustrated.

Statistics

010020020072008200920102011201220132014201520162017
Citations per Year

213 Citations

Semantic Scholar estimates that this publication has 213 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Nilsson2006BiexponentialFO, title={Biexponential fitting of diffusion-ordered NMR data: practicalities and limitations.}, author={Mathias Nilsson and Mark A Connell and Adrian L. Davis and Gareth A Morris}, journal={Analytical chemistry}, year={2006}, volume={78 9}, pages={3040-5} }