Biexponential Kinetics of (R)‐α‐[3H]Methylhistamine Binding to the Rat Brain H3 Histamine Receptor

@article{West1990BiexponentialKO,
  title={Biexponential Kinetics of (R)‐α‐[3H]Methylhistamine Binding to the Rat Brain H3 Histamine Receptor},
  author={R. West and A. Zweig and Russell T. Granzow and M. Siegel and R. Egan},
  journal={Journal of Neurochemistry},
  year={1990},
  volume={55}
}
  • R. West, A. Zweig, +2 authors R. Egan
  • Published 1990
  • Chemistry
  • Journal of Neurochemistry
  • Abstract: The H3 histamine receptor is a high‐affinity receptor reported to mediate inhibition of CNS histidine decarboxylase activity and depolarization‐induced histamine release. We have used (R)‐α‐[3H]methylhistamine, a specific, high‐affinity agonist, to characterize ligand binding to this receptor. Saturation binding studies with rat brain membranes disclosed a single class of sites (KD= 0.68 nM; Bmax= 78 fmol/mg of protein). Competition binding assays also yielded an apparently single… CONTINUE READING
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