Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5.

@article{Meinild1998BidirectionalWF,
  title={Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5.},
  author={A K Meinild and Dan Arne Klaerke and Thomas Zeuthen},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 49},
  pages={
          32446-51
        }
}
The dimensions of the aqueous pore in aquaporins (AQP) 0, 1, 2, 3, 4, and 5 expressed in Xenopus laevis oocytes were probed by comparing the ability of various solutes to generate osmotic flow. By improved techniques, volume flows were determined from initial rates of changes. Identical values for the osmotic water permeability (Lp) were obtained in swelling as in shrinkage experiments demonstrating, for the first time, that aquaporins are bidirectional. The reflection coefficients (sigma) of… CONTINUE READING

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