Bidirectional transcription of Linc00441 and RB1 via H3K27 modification-dependent way promotes hepatocellular carcinoma

@inproceedings{Tang2017BidirectionalTO,
  title={Bidirectional transcription of Linc00441 and RB1 via H3K27 modification-dependent way promotes hepatocellular carcinoma},
  author={Junwei Tang and Yu Xie and Xiaoliang Xu and Yin Yin and Runqiu Jiang and Lei Deng and Zhongming Tan and Venkatanarayana Gangarapu and J Tang and Beicheng Sun},
  booktitle={Cell death & disease},
  year={2017}
}
The retinoblastoma gene (RB1), a known tumor-suppressor gene (TSG), was decreased in multiple cancers including hepatocellular carcinoma (HCC). Here we focused on the bidirectional transcripted long noncoding RNA (Linc00441) with neighbor gene RB1 to investigate whether Linc00441 is involved in the suppression of RB1 in HCC. We found that aberrant upregulated intranuclear Linc00441 was reversely correlated with RB1 expression in human HCC samples. The gain- and loss-of-function investigation… CONTINUE READING
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