Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms.

@article{Brandi1995BidirectionalRO,
  title={Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms.},
  author={Maria Luisa Brandi and Mika V J Hukkanen and Tsuyoshi Umeda and Niloufar Moradi-Bidhendi and S. C. S. Bianchi and Steven S. Gross and JuliaM. Polak and Ian D. MacIntyre},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 7},
  pages={
          2954-8
        }
}
Nitric oxide (NO) produces rapid osteoclast detachment and contraction in vitro, and this effect is accompanied by a profound inhibition of bone resorption. Work by others has confirmed these findings in vivo: inhibition of NO synthase [NOS; L-arginine, NADPH: oxygen oxidoreductase (NO-forming), EC 1.14.13.39] in normal rats is followed by increased bone resorption reflected by a marked loss in bone mineral density. In our present study, immunocytochemistry and Northern blotting show the… CONTINUE READING

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