Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms.

@article{Brandi1995BidirectionalRO,
  title={Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms.},
  author={M. Brandi and M. Hukkanen and T. Umeda and N. Moradi-Bidhendi and S. Bianchi and S. Gross and J. Polak and I. MacIntyre},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92},
  pages={2954 - 2958}
}
  • M. Brandi, M. Hukkanen, +5 authors I. MacIntyre
  • Published 1995
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • Nitric oxide (NO) produces rapid osteoclast detachment and contraction in vitro, and this effect is accompanied by a profound inhibition of bone resorption. Work by others has confirmed these findings in vivo: inhibition of NO synthase [NOS; L-arginine, NADPH: oxygen oxidoreductase (NO-forming), EC 1.14.13.39] in normal rats is followed by increased bone resorption reflected by a marked loss in bone mineral density. In our present study, immunocytochemistry and Northern blotting show the… CONTINUE READING
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