Bidirectional regulation of neurogenesis by neuronal nitric oxide synthase derived from neurons and neural stem cells.


It has been demonstrated that neuronal nitric oxide synthase (nNOS) negatively regulates adult neurogenesis. However, the cellular and molecular mechanisms underlying are poorly understood. Here, we show that nNOS from neural stem cells (NSCs) and from neurons play opposite role in regulating neurogenesis. The NSCs treated with nNOS inhibitor N(5)-(1-imino… (More)
DOI: 10.1002/stem.522


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