Bidirectional regulation of DARPP-32 phosphorylation by dopamine.


Dopamine has been shown to stimulate phosphorylation of DARPP-32, a phosphoprotein highly enriched in medium-sized spiny neurons of the neostriatum. Here, we investigated the contribution of D1-like and D2-like dopamine receptors in the regulation of DARPP-32 phosphorylation in mouse striatal slices. D1-like and D2-like receptors had opposing effects on the… (More)


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@article{Nishi1997BidirectionalRO, title={Bidirectional regulation of DARPP-32 phosphorylation by dopamine.}, author={Akinori Nishi and Gretchen L. Snyder and Paul Greengard}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={1997}, volume={17 21}, pages={8147-55} }