Bidirectional prefrontal-hippocampal interactions support context-guided memory

  title={Bidirectional prefrontal-hippocampal interactions support context-guided memory},
  author={Ryan J Place and Anja Farovik and Marco Brockmann and Howard Eichenbaum},
  booktitle={Nature Neuroscience},
We compared the dynamics of hippocampal and prefrontal interactions in rats as they used spatial contexts to guide the retrieval of object memories. Functional connectivity analysis indicated a flow of contextual information from the hippocampus to prefrontal cortex upon the rat's entry into the spatial context. Conversely, upon the onset of object sampling, the direction of information flow reversed, consistent with prefrontal control over the retrieval of context-appropriate hippocampal… CONTINUE READING
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