Bidirectional modulation of classical fear conditioning in mice by 5-HT<ce:inf loc=post>1A</ce:inf> receptor ligands with contrasting intrinsic activities

@article{Youn2009BidirectionalMO,
  title={Bidirectional modulation of classical fear conditioning in mice by 5-HT<ce:inf loc=post>1A</ce:inf> receptor ligands with contrasting intrinsic activities},
  author={Jiun Youn and Ilga Misane and Therese M. Eriksson and Mark John Millan and Oliver Stiedl},
  journal={Neuropharmacology},
  year={2009},
  volume={57},
  pages={567-576}
}
5-HT(1A) receptors are implicated in the modulation of cognitive processes including encoding of fear learning. However, their exact role has remained unclear due to contrasting contributions of pre- vs. postsynaptic 5-HT(1A) receptors. Therefore, their role in fear conditioning was studied in mice using the selective ligand S15535, which fully activates 5-HT(1A) autoreceptors, yet only weakly stimulates their postsynaptic counterparts. The effects of S15535 were compared to those of the full… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…