Bidirectional modulation of basal forebrain N-methyl-d-aspartate receptor function differentially affects visual attention but not visual discrimination performance

@article{Turchi2001BidirectionalMO,
  title={Bidirectional modulation of basal forebrain N-methyl-d-aspartate receptor function differentially affects visual attention but not visual discrimination performance},
  author={Janita Turchi and Martin Sarter},
  journal={Neuroscience},
  year={2001},
  volume={104},
  pages={407-417}
}
Basal forebrain neuronal circuits, specifically the corticopetal cholinergic system, mediate attentional abilities. The effects of infusions of N-methyl-D-aspartate (NMDA) and the competitive NMDA receptor antagonist DL-2-amino-5-phosphonovaleric acid (APV) into the basal forebrain were assessed in rats trained in an operant task designed to generate measures of sustained attention performance. Control animals were trained in a cued visual discrimination task devoid of explicit demands on… CONTINUE READING
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