Bidirectional modulation of adipogenesis by the secreted protein Ccdc80/DRO1/URB.

Abstract

Adipocyte-secreted proteins play important roles in metabolic regulation through autocrine, paracrine, and endocrine mechanisms. Using transcriptional profiling, we identified coiled-coil domain containing 80 (Ccdc80; also known as DRO1 and URB) as a novel secreted protein highly expressed in white adipose tissue. In 3T3-L1 cells Ccdc80 is expressed and… (More)
DOI: 10.1074/jbc.M809535200

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