Bidirectional modification of CA1 synapses in the adult hippocampus in vivo

@article{Heynen1996BidirectionalMO,
  title={Bidirectional modification of CA1 synapses in the adult hippocampus in vivo},
  author={Arnold J. Heynen and Wickliffe C. Abraham and Mark F. Bear},
  journal={Nature},
  year={1996},
  volume={381},
  pages={163-166}
}
MEMORIES are believed to be stored by synaptic modifications. One type of activity-dependent synaptic modification, long-term potentiation (LTP), has received considerable attention as a possible memory mechanism, particularly in hippocampus1. However, use-dependent decreases in synaptic strength can store information as well. A form of homosynaptic long-term depression (LTD) has been described and widely studied in the CA1 region of the developing hippocampus in vitro2–4. However, the… CONTINUE READING

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