Bidirectional membrane transport: simulations of transport inhibition in uptake studies explain data obtained with flavonoids.

@article{Ofer2006BidirectionalMT,
  title={Bidirectional membrane transport: simulations of transport inhibition in uptake studies explain data obtained with flavonoids.},
  author={Monika Ofer and Peter Langguth and Hilde Spahn-Langguth},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2006},
  volume={29 3-4},
  pages={251-8}
}
The purpose of the simulations was to obtain an estimate of concentration-dependent uptake curves when two counteracting transporters are present. On the basis of this experimental data obtained with a pair of ovarian carcinoma cell lines, one of which was not expressing the exsorptive transporter P-glycoprotein and one of which was an MDR1-transfected, P-glycoprotein expressing variant, the kinetics of cellular uptake of the radiolabel (3)H-talinolol were calculated and the inhibitory… CONTINUE READING

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