Bidirectional increase in permeability of nuclear envelope upon poliovirus infection and accompanying alterations of nuclear pores.

@article{Belov2004BidirectionalII,
  title={Bidirectional increase in permeability of nuclear envelope upon poliovirus infection and accompanying alterations of nuclear pores.},
  author={George A Belov and Peter V Lidsky and Olga V Mikitas and D. Caroline Egger and Konstantin A. Lukyanov and K. A. Bienz and Vadim I Agol},
  journal={Journal of virology},
  year={2004},
  volume={78 18},
  pages={
          10166-77
        }
}
Poliovirus and some other picornaviruses trigger relocation of certain nuclear proteins into the cytoplasm. Here, by using a protein changing its fluorescence color with time and containing a nuclear localization signal (NLS), we demonstrate that the poliovirus-triggered relocation is largely due to the exit of presynthesized nuclear protein into the cytoplasm. The leakiness of the nuclear envelope was also documented by the inability of nuclei from digitonin-permeabilized, virus-infected (but… CONTINUE READING
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