Bidirectional entry of poliovirus into polarized epithelial cells.

  title={Bidirectional entry of poliovirus into polarized epithelial cells.},
  author={Simon P Tucker and Christopher. Thornton and Eckard J Wimmer and Richard W. Compans},
  journal={Journal of virology},
  volume={67 1},
The interactions of viruses with polarized epithelial cells are of some significance to the pathogenesis of disease because these cell types comprise the primary barrier to many virus infections and also serve as the sites for virus release from the host. Poliovirus-epithelial cell interactions are of particular interest since this virus is an important enteric pathogen and the host cell receptor has been identified. In this study, poliovirus was observed to adsorb to both the apical and… CONTINUE READING
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