Bidirectional enantioselective effects of the GABAB receptor agonist baclofen in two mouse models of excessive ethanol consumption.

@article{Kasten2015BidirectionalEE,
  title={Bidirectional enantioselective effects of the GABAB receptor agonist baclofen in two mouse models of excessive ethanol consumption.},
  author={Chelsea R Kasten and Shelby N. Blasingame and Stephen L. Boehm},
  journal={Alcohol},
  year={2015},
  volume={49 1},
  pages={
          37-46
        }
}
The GABAB receptor agonist baclofen has been studied extensively in preclinical models of alcohol-use disorders, yet results on its efficacy have been uncertain. Racemic baclofen, which is used clinically, can be broken down into separate enantiomers of the drug. Baclofen has been shown to produce enantioselective effects in behavioral assays, including those modeling reflexive and sexual behavior. The current studies sought to characterize the enantioselective effects of baclofen in two… CONTINUE READING
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