Bidirectional effects of β-carbolines in reflex epilepsy

@article{Chapman1987BidirectionalEO,
  title={Bidirectional effects of $\beta$-carbolines in reflex epilepsy},
  author={Astrid G. Chapman and Giovambattista De Sarro and M. Premachandra and Brian S. Meldrum},
  journal={Brain Research Bulletin},
  year={1987},
  volume={19},
  pages={337-346}
}
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34 Citations
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34 Citations

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Differential effects of antiepileptic drugs and β-carbolines on seizures induced by excitatory amino acids
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Seizure susceptibility to various convulsant stimuli in dystrophin-deficient mdx mice
Inhibition of photosensitive seizures in man by the β-carboline, ZK 95962, a selective benzodiazepine receptor agonist
Blockade of FG 7142 kindling by anticonvulsants acting at sites distant from the benzodiazepine receptor
1,4-Benzodiazepine derivatives as anticonvulsant agents in DBA/2 mice.
Seizure susceptibility to various convulsant stimuli of knockout interleukin-6 mice
Benzodiazepine Receptor Affinities, Behavioral, and Anticonvulsant Activity of 2-Aryl-2,5-dihydropyridazino[4,3-b]indol- 3(3H)-ones in Mice
Vigabatrin and tiagabine are pharmacologically different drugs. A pre-clinical study
TLDR
It is suggested that vigabatrin and tiagabine have differing efficacy in experimental seizure models and distinct neurochemical effects, and it is possible that these drugs will have different spectra of activity and toxicity profiles in human epilepsy.
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References

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Behavioural and convulsant actions of two methyl esters of beta-carboline-3-carboxylic acid in photosensitive baboons and in DBA/2 mice.
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Ethyl β-carboline carboxylate lowers seizure threshold and antagonizes flurazepam-induced sedation in rats
TLDR
It is reported here that, in contrast to the benzodiazepines, β-CCE lowers seizure threshold and reverses the sedative effect of flurazepam, and if β- CCE has a close structural relationship to the endogenous ligand, benzodiazines may be antagonistic at the receptor site.
Bidirectional effects of beta-carbolines in rats with spontaneous petit mal-like scizures
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Evaluation of the muscle relaxant properties of a novel β‐carboline, ZK 93423 in rats and cats
TLDR
The present results demonstrate that ZK 93423 exerts a potent muscle relaxant action due to a specific interaction with benzodiazepine receptors, however, its profile of actions on spinal motor mechanisms is not identical to that of diazepam.
beta-Carboline-3-carboxylate-t-butyl ester: a selective BZ1 benzodiazepine receptor antagonist.
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