Bidirectional effects of β-carbolines in reflex epilepsy

@article{Chapman1987BidirectionalEO,
  title={Bidirectional effects of $\beta$-carbolines in reflex epilepsy},
  author={Astrid G. Chapman and Giovambattista De Sarro and M. Premachandra and Brian S. Meldrum},
  journal={Brain Research Bulletin},
  year={1987},
  volume={19},
  pages={337-346}
}
Seizure susceptibility to various convulsant stimuli of knockout interleukin-6 mice
Vigabatrin and tiagabine are pharmacologically different drugs. A pre-clinical study
TLDR
It is suggested that vigabatrin and tiagabine have differing efficacy in experimental seizure models and distinct neurochemical effects, and it is possible that these drugs will have different spectra of activity and toxicity profiles in human epilepsy.
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References

SHOWING 1-10 OF 53 REFERENCES
Ethyl β-carboline carboxylate lowers seizure threshold and antagonizes flurazepam-induced sedation in rats
TLDR
It is reported here that, in contrast to the benzodiazepines, β-CCE lowers seizure threshold and reverses the sedative effect of flurazepam, and if β- CCE has a close structural relationship to the endogenous ligand, benzodiazines may be antagonistic at the receptor site.
DMCM: a potent convulsive benzodiazepine receptor ligand.
  • E. Petersen
  • Biology, Chemistry
    European journal of pharmacology
  • 1983
Evaluation of the muscle relaxant properties of a novel β‐carboline, ZK 93423 in rats and cats
TLDR
The present results demonstrate that ZK 93423 exerts a potent muscle relaxant action due to a specific interaction with benzodiazepine receptors, however, its profile of actions on spinal motor mechanisms is not identical to that of diazepam.
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