Bidirectional effect of met-enkephalin on macrophage effector functions

  title={Bidirectional effect of met-enkephalin on macrophage effector functions},
  author={PhD Gabriella F{\'o}ris and George A. Medgyesi and M{\'a}ty{\'a}s Hauck},
  journal={Molecular and Cellular Biochemistry},
Met-enkephalin (ME) exerts a bimodal effect on functional activities of rat peritoneal macrophages (PM); in a range of low concentration (10-9-10-7 M) antibody dependent cellular cytotoxicity (ADCC)was markedly stimulated with a simultaneous decrease of Fcγ receptor (FcγR) mediated phagocytosis while the opposite was observed at 10-6-10-5 M concentrations. Studying the possible underlying mechanism(s) the followings were recorded: (1) ME in all applied concentrations induced an early Na+ influx… CONTINUE READING