Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons.

  title={Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons.},
  author={Jeremy K. Seamans and Natalia Gorelova and Daniel Durstewitz and Chao Yang},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={21 10},
Dopamine regulates the activity of neural networks in the prefrontal cortex that process working memory information, but its precise biophysical actions are poorly understood. The present study characterized the effects of dopamine on GABAergic inputs to prefrontal pyramidal neurons using whole-cell patch-clamp recordings in vitro. In most pyramidal cells, dopamine had a temporally biphasic effect on evoked IPSCs, producing an initial abrupt decrease in amplitude followed by a delayed increase… CONTINUE READING
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Bidirectional regulation of GABAergic inhibition in the prefrontal cortex by dopamine

  • JK Seamans, N Gorelova, D Durstewitz, CR Yang
  • Soc Neurosci Abstr
  • 2000
2 Excerpts

Dopamine - mediated stabilization of delayperiod activity in a network model of prefrontal cortex

  • D Durstewitz, JK Seamans, TJ Sejnowski
  • J Neurophysiol
  • 2000
3 Excerpts

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