Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

@article{Wegmann1993BidirectionalCI,
  title={Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?},
  author={Thomas Wegmann and H Lin and Larry Guilbert and Tim R. Mosmann},
  journal={Immunology today},
  year={1993},
  volume={14 7},
  pages={353-6}
}
Pregnant females are susceptible to intracellular pathogens and are biased towards humoral rather than cell-mediated immunity. Since TH1 cytokines compromise pregnancy and TH2 cytokines are produced at the maternal-fetal interface, we hypothesize that these TH2 cytokines inhibit TH1 responses, improving fetal survival but impairing responses against some pathogens. 
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