Bidirectional cargo transport: moving beyond tug of war

  title={Bidirectional cargo transport: moving beyond tug of war},
  author={William O. Hancock},
  journal={Nature Reviews Molecular Cell Biology},
Vesicles, organelles and other intracellular cargo are transported by kinesin and dynein motors, which move in opposite directions along microtubules. This bidirectional cargo movement is frequently described as a 'tug of war' between oppositely directed molecular motors attached to the same cargo. However, although many experimental and modelling studies support the tug-of-war paradigm, numerous knockout and inhibition studies in various systems have found that inhibiting one motor leads to… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.
83 Citations
175 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 83 extracted citations


Publications referenced by this paper.
Showing 1-10 of 175 references

Single‐molecule biophysics of kinesin family motor proteins

  • J.O.L. Andreasson
  • Thesis, Stanford Univ
  • 2013

Similar Papers

Loading similar papers…