Bidirectional cargo transport: moving beyond tug of war

@article{Hancock2014BidirectionalCT,
  title={Bidirectional cargo transport: moving beyond tug of war},
  author={William O. Hancock},
  journal={Nature Reviews Molecular Cell Biology},
  year={2014},
  volume={15},
  pages={615-628}
}
Vesicles, organelles and other intracellular cargo are transported by kinesin and dynein motors, which move in opposite directions along microtubules. This bidirectional cargo movement is frequently described as a 'tug of war' between oppositely directed molecular motors attached to the same cargo. However, although many experimental and modelling studies support the tug-of-war paradigm, numerous knockout and inhibition studies in various systems have found that inhibiting one motor leads to… CONTINUE READING
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Single‐molecule biophysics of kinesin family motor proteins

  • J.O.L. Andreasson
  • Thesis, Stanford Univ
  • 2013

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