Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells.

@article{Siupka2017BidirectionalAT,
  title={Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells.},
  author={Piotr Siupka and Maria Ns Hersom and Karin Lykke-Hartmann and Kasper Bendix Johnsen and Louiza Bohn Thomsen and Thomas Lars Andresen and Torben Moos and N Joan Abbott and Birger Brodin and Morten S Nielsen},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2017},
  volume={37 7},
  pages={
          2598-2613
        }
}
Brain capillary endothelium mediates the exchange of nutrients between blood and brain parenchyma. This barrier function of the brain capillaries also limits passage of pharmaceuticals from blood to brain, which hinders treatment of several neurological disorders. Receptor-mediated transport has been suggested as a potential pharmaceutical delivery route across the brain endothelium, e.g. reports have shown that the transferrin receptor (TfR) facilitates transcytosis of TfR antibodies, but it… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 93 references

Similar Papers

Loading similar papers…