• Biology, Medicine
  • Published in Journal of immunology 1977

Bidirectional amplification of macrophage-lymphocyte interactions: enhanced lymphocyte activation factor production by activated adherent mouse peritoneal cells.

@article{Meltzer1977BidirectionalAO,
  title={Bidirectional amplification of macrophage-lymphocyte interactions: enhanced lymphocyte activation factor production by activated adherent mouse peritoneal cells.},
  author={Monte S. Meltzer and Joost J Oppenheim},
  journal={Journal of immunology},
  year={1977},
  volume={118 1},
  pages={
          77-82
        }
}
Adherent peritoneal cells (90 to 95% macrophages) from mice injected with Mycobacterium bovis, strain BCG, or certain noninfectious agents such as pyran copolymer or phytohemagglutinin showed increased chemotactic and tumoricidal capacity in vitro. These activated macrophages elaborated 2 to 5 times more lymphocyte-activating factor (LAF) in vitro than equal numbers of adherent cells from untreated mice. In contrast, adherent PC from mice treated with thioglycollate or mineral oil were not… CONTINUE READING

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