Bidirectional Parallel Fiber Plasticity in the Cerebellum under Climbing Fiber Control

@article{Coesmans2004BidirectionalPF,
  title={Bidirectional Parallel Fiber Plasticity in the Cerebellum under Climbing Fiber Control},
  author={Michiel Coesmans and John T. Weber and Chris I. De Zeeuw and Christian R W Hansel},
  journal={Neuron},
  year={2004},
  volume={44},
  pages={691-700}
}
Cerebellar parallel fiber (PF)-Purkinje cell (PC) synapses can undergo postsynaptically expressed long-term depression (LTD) or long-term potentiation (LTP) depending on whether or not the climbing fiber (CF) input is coactivated during tetanization. Here, we show that modifications of the postsynaptic calcium load using the calcium chelator BAPTA or photolytic calcium uncaging result in a reversal of the expected polarity of synaptic gain change. At higher concentrations, BAPTA blocks PF-LTP… CONTINUE READING
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Theory for mission between a granule cell and a Purkinje cell in rat cerebellar the development of neuron selectivity : orientation specificity and culture

  • E. L. Bienenstock, L. N. Cooper, P. W. Munro
  • Neurosci . Lett .
  • 1982
Highly Influential
3 Excerpts

Cerebellum - quired for the induction and heterosynaptic spread of long - term dependent learning : the role of multiple plasticity mechanisms . potentiation in rat cerebellar slices

  • S. Jacoby, R. E. Sims, N. A. Hartell, E. S. Boyden, A. Katoh, J. L. Raymond
  • J . Physiol .
  • 2004

Cerebellar Calcium signals in long-term potentiation and long-term depression. LTD and learning-dependent timing of conditioned eyelid reCan

  • S.K.E. Koekkoek, H. C. Hulscher, +8 authors C. I. De Zeeuw
  • J. Physiol. Pharmacol
  • 2003
1 Excerpt

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