Bidirectional Parallel Fiber Plasticity in the Cerebellum under Climbing Fiber Control

  title={Bidirectional Parallel Fiber Plasticity in the Cerebellum under Climbing Fiber Control},
  author={Michiel Coesmans and John T. Weber and Chris I. De Zeeuw and Christian R W Hansel},
Cerebellar parallel fiber (PF)-Purkinje cell (PC) synapses can undergo postsynaptically expressed long-term depression (LTD) or long-term potentiation (LTP) depending on whether or not the climbing fiber (CF) input is coactivated during tetanization. Here, we show that modifications of the postsynaptic calcium load using the calcium chelator BAPTA or photolytic calcium uncaging result in a reversal of the expected polarity of synaptic gain change. At higher concentrations, BAPTA blocks PF-LTP… CONTINUE READING
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