Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex

@article{Wang2011BidirectionalCO,
  title={Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex},
  author={Fei Wang and Jun Zhu and Hong Zhu and Qi Zhang and Zhanmin Lin and Hailan Hu},
  journal={Science},
  year={2011},
  volume={334},
  pages={693 - 697}
}
Manipulation of the neural circuit determining social status allows subordinate mice to move up the hierarchy and dominant mice to go down. Dominance hierarchy has a profound impact on animals’ survival, health, and reproductive success, but its neural circuit mechanism is virtually unknown. We found that dominance ranking in mice is transitive, relatively stable, and highly correlates among multiple behavior measures. Recording from layer V pyramidal neurons of the medial prefrontal cortex… Expand
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