Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex

  title={Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex},
  author={Fei Wang and Jun Zhu and Hong Zhu and Qi Zhang and Zhanmin Lin and Hailan Hu},
  pages={693 - 697}
Manipulation of the neural circuit determining social status allows subordinate mice to move up the hierarchy and dominant mice to go down. Dominance hierarchy has a profound impact on animals’ survival, health, and reproductive success, but its neural circuit mechanism is virtually unknown. We found that dominance ranking in mice is transitive, relatively stable, and highly correlates among multiple behavior measures. Recording from layer V pyramidal neurons of the medial prefrontal cortex… 

The Neural Circuit Architecture of Social Hierarchy in Rodents and Primates

Comparing and integrating findings from rodent and primate studies is compared to create a model of the neural and cellular networks supporting social hierarchies, both from a macro (i.e., circuits) to a micro-scale perspective (microcircuits and synapses).

Social hierarchy regulates ocular dominance plasticity in adult male mice

It is shown that social rank, as assessed by competition for a running wheel, influences ocular dominance plasticity in adult male mice through higher-order cortices, most likely the medial prefrontal cortex.

Nucleus accumbens dichotomically controls social dominance in male mice

By introducing lesions to both NAc subregions, the shell and core, a causal relationship is established and a neural substrate for social dominance is identified, implying the potential for a therapeutic strategy for treating related psychiatric disorders.

History of winning remodels thalamo-PFC circuit to reinforce social dominance

In vivo optogenetic-based long-term potentiation and depression experiments establish that the mediodorsal thalamic input to the dmPFC mediates long-lasting changes in the social dominance status that are affected by history of winning.

Molecular and Circuit Architecture of Social Hierarchy

The data suggest a model in which cellular, molecular and biophysical plasticity in a thalamocortical circuit controls the expression of social status, and establish a robust behavioral paradigm to explore the establishment of hierarchy among groups of unfamiliar males.

Cortical dynamics underlying social behavior in dominance hierarchy and spatial navigation

A simplified goal-directed spatial navigation task in mice is implemented and it is found that the social context exerts significant influence on individual decision-making, even when efficient navigation rules leading to reward had been previously learned.

A cortical-hypothalamic circuit decodes social rank and promotes dominance behavior

A cortico-hypothalamic circuit by which mPFC exerts top-down modulation of social dominance is revealed, and cells that project to the lateral hypothalamus contribute to the prediction of social rank and promote dominance behavior during the reward competition are demonstrated.

Cortical ensembles orchestrate social competition through hypothalamic outputs.

It is demonstrated that mPFC cells that project to the lateral hypothalamus promote dominance behaviour during reward competition, and a cortico-hypothalamic circuit by which themPFC exerts top-down modulation of social dominance is revealed.

Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling

This work validated a significant increase in the expression of Npy1r, a receptor known to play a role in maternal care, anxiety, foraging, and regulation of group behavior, and determined that this receptor plays a key role in enhancing GABAergic currents in mice that experience maternal deprivation.



Social Network Size Affects Neural Circuits in Macaques

Control monkeys that had been living in social groups set to different sizes revealed that living in larger groups caused increases in gray matter in mid-superior temporal sulcus and rostral prefrontal cortex and increased coupling of activity in frontal and temporal cortex.

The Effect of Social Experience on Serotonergic Modulation of the Escape Circuit of Crayfish

The neuromodulator serotonin has widespread effects in the nervous systems of many animals, often influencing aggression and dominance status. In crayfish, the effect of serotonin on the neural

Neocortical excitation/inhibition balance in information processing and social dysfunction

Elevation, but not reduction, of cellular E/I balance within the mouse medial prefrontal cortex was found to elicit a profound impairment in cellular information processing, associated with specific behavioural impairments and increased high-frequency power in the 30–80 Hz range, which have both been observed in clinical conditions in humans.

Neural basis of social status hierarchy across species

  • J. Chiao
  • Biology, Psychology
    Current Opinion in Neurobiology
  • 2010

Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex

Cellular indicators of functional activity, including the immediate early genes (IEGs) zif268 (egr1), c-fos, and arc, in the prefrontal cortex of clinically depressed humans obtained postmortem and mice after chronic social defeat stress indicate that the activity of the mPFC is a key determinant of depression-like behavior, as well as antidepressant responses.

Nicotinic Acetylcholine Receptor β2 Subunits in the Medial Prefrontal Cortex Control Attention

Findings show that β2-subunit expression in the PrL PFC is sufficient for endogenous nAChR-mediated cholinergic regulation of attentional performance and completely restored the attentional deficit but did not affect impulsive and motivational behavior.

The Influence of Social Hierarchy on Primate Health

Whether it is high- or low-ranking animals that are most stressed in a dominance hierarchy turns out to vary as a function of the social organization in different species and populations are considered.

Differential projections of the infralimbic and prelimbic cortex in the rat

The pattern of IL projections is consistent with a role for IL in the control of visceral/autonomic activity homologous to the orbitomedial prefrontal cortex of primates, whereas those of PL are consistent withA role for PL in limbic‐cognitive functions homologously to the dorsolateral prefrontal cortex in primates.