Bidirectional Control of Generalized Epilepsy Networks via Rapid Real-Time Switching of Firing Mode

Abstract

Thalamic relay neurons have well-characterized dual firing modes: bursting and tonic spiking. Studies in brain slices have led to a model in which rhythmic synchronized spiking (phasic firing) in a population of relay neurons leads to hyper-synchronous oscillatory cortico-thalamo-cortical rhythms that result in absence seizures. This model suggests that… (More)
DOI: 10.1016/j.neuron.2016.11.026

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