Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence

  title={Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence},
  author={Mingming Chen and Daqing Guo and Tiebin Wang and Wei Jing and Yang Xia and Peng Xu and Cheng Luo and Pedro A. Vald{\'e}s-Sosa and Dezhong Yao},
  journal={PLoS Computational Biology},
Absence epilepsy is believed to be associated with the abnormal interactions between the cerebral cortex and thalamus. Besides the direct coupling, anatomical evidence indicates that the cerebral cortex and thalamus also communicate indirectly through an important intermediate bridge–basal ganglia. It has been thus postulated that the basal ganglia might play key roles in the modulation of absence seizures, but the relevant biophysical mechanisms are still not completely established. Using a… 

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