Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence

@article{Chen2014BidirectionalCO,
  title={Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence},
  author={Mingming Chen and Daqing Guo and Tiebin Wang and Wei Jing and Yang Xia and Peng Xu and Cheng Luo and Pedro A. Vald{\'e}s-Sosa and Dezhong Yao},
  journal={PLoS Computational Biology},
  year={2014},
  volume={10}
}
Absence epilepsy is believed to be associated with the abnormal interactions between the cerebral cortex and thalamus. Besides the direct coupling, anatomical evidence indicates that the cerebral cortex and thalamus also communicate indirectly through an important intermediate bridge–basal ganglia. It has been thus postulated that the basal ganglia might play key roles in the modulation of absence seizures, but the relevant biophysical mechanisms are still not completely established. Using a… 
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A basal ganglia-corticothalamic network model is built and it is determined that the final presentation position of the epileptic slow spike waves is not limited to the cerebral cortex and the delay in the network was observed to be a critical factor for inducing transitions between different types of absence epileptiform activities.
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TLDR
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This work argues for a novel theory according to which the BG drive the oscillatory patterns of activity occurring during the seizures, and it predicts that well-timed transient excitatory inputs to the cortex advance the termination of absence seizures.
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