Bidirectional, optical sign-dependent regulation of BMP2 gene expression in chick retinal pigment epithelium.

@article{Zhang2012BidirectionalOS,
  title={Bidirectional, optical sign-dependent regulation of BMP2 gene expression in chick retinal pigment epithelium.},
  author={Yan Zhang and Yue Liu and Christine F. Wildsoet},
  journal={Investigative ophthalmology & visual science},
  year={2012},
  volume={53 10},
  pages={6072-80}
}
PURPOSE We explored the role of bone morphogenic protein 2 (BMP2) in defocus-induced ocular growth using gene expression changes in RPE as a surrogate. METHODS Young White-Leghorn chickens were used in this study. Normal gene expression of BMP2 and its receptors was examined in retina, RPE, and choroid, and BMP2 protein expression assessed in the same tissues using Western blots and immunohistochemistry. Quantitative PCR (qPCR) was used to assess the effects of short-term exposure (2 or 48… CONTINUE READING

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Mentioned Connections BETA
ChoroidSibling in part ofRetina
Normal gene expression of BMP2 and its receptors was examined in retina , RPE , and choroid , and BMP2 protein expression assessed in the same tissues using Western blots and immunohistochemistry .
In the eyes of untreated chickens , BMP2 mRNA was expressed more highly in RPE compared to retina and choroid and all three tissues expressed BMP2 protein .
RetinaSibling in part ofChoroid
In the eyes of untreated chickens , BMP2 mRNA was expressed more highly in RPE compared to retina and choroid and all three tissues expressed BMP2 protein .
Normal gene expression of BMP2 and its receptors was examined in retina , RPE , and choroid , and BMP2 protein expression assessed in the same tissues using Western blots and immunohistochemistry .
EyeNo subtypeChoroid
BMP2 was up - regulated in the RPE from eyes wearing + 10 D lenses , which exhibited shorter than normal vitreous chambers ( VCDs ) and thickened choroids , while BMP2 was down - regulated in the RPE from eyes wearing -10 D lenses , which developed enlarged VCDs .
BMP2 was up - regulated in the RPE from eyes wearing + 10 D lenses , which exhibited shorter than normal vitreous chambers ( VCDs ) and thickened choroids , while BMP2 was down - regulated in the RPE from eyes wearing -10 D lenses , which developed enlarged VCDs .
In the eyes of untreated chickens , BMP2 mRNA was expressed more highly in RPE compared to retina and choroid and all three tissues expressed BMP2 protein .
EyeNo subtypeRetina
In the eyes of untreated chickens , BMP2 mRNA was expressed more highly in RPE compared to retina and choroid and all three tissues expressed BMP2 protein .
RetinaNo subtypeEye
In the eyes of untreated chickens , BMP2 mRNA was expressed more highly in RPE compared to retina and choroid and all three tissues expressed BMP2 protein .
RetinaAnatomic structure is physical part ofEye
In the eyes of untreated chickens , BMP2 mRNA was expressed more highly in RPE compared to retina and choroid and all three tissues expressed BMP2 protein .
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