Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

@article{Tobaben2011BidmediatedMD,
  title={Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons},
  author={Svenja Tobaben and Julia Grohm and Alexander Seiler and Marcus Conrad and Nikolaus Plesnila and Carsten Culmsee},
  journal={Cell Death and Differentiation},
  year={2011},
  volume={18},
  pages={282-292}
}
Glutamate toxicity involves increases in intracellular calcium levels and enhanced formation of reactive oxygen species (ROS) causing neuronal dysfunction and death in acute and chronic neurodegenerative disorders. The molecular mechanisms mediating glutamate-induced ROS formation are, however, still poorly defined. Using a model system that lacks glutamate-operated calcium channels, we demonstrate that glutamate-induced acceleration of ROS levels occurs in two steps and is initiated by… CONTINUE READING