Bid-independent mitochondrial activation in tumor necrosis factor alpha-induced apoptosis and liver injury.

Abstract

The death receptor apoptosis pathway is intimately connected with the mitochondrial apoptosis pathway. Bid is a BH3-only pro-death Bcl-2 family protein and is the major molecule linking the two pathways. Bid-mediated mitochondrial activation occurs early and is responsible for the prompt progress of tumor necrosis factor alpha (TNF-alpha)-induced apoptosis… (More)

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@article{Chen2007BidindependentMA, title={Bid-independent mitochondrial activation in tumor necrosis factor alpha-induced apoptosis and liver injury.}, author={Xiaoyun Chen and Wenxing Ding and H F Ni and Wentao Gao and Ying-hong Shi and Andrea A Gambotto and Jia Fan and Amer A. Beg and X. F. Yin}, journal={Molecular and cellular biology}, year={2007}, volume={27 2}, pages={541-53} }