Bid binding to negatively charged phospholipids may not be required for its pro-apoptotic activity in vivo.

@article{Manara2009BidBT,
  title={Bid binding to negatively charged phospholipids may not be required for its pro-apoptotic activity in vivo.},
  author={A. Manara and Jennefer Lindsay and Marta Marchioretto and Alessandra Astegno and Andrew P Gilmore and Mauro Degli Esposti and Massimo Crimi},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1791 10},
  pages={997-1010}
}
Bid is a ubiquitous pro-apoptotic member of the Bcl-2 family that has been involved in a variety of pathways of cell death. Unique among pro-apoptotic proteins, Bid is activated after cleavage by the apical caspases of the extrinsic pathway; subsequently it moves to mitochondria, where it promotes the release of apoptogenic proteins in concert with other Bcl-2 family proteins like Bak. Diverse factors appear to modulate the pro-apoptotic action of Bid, from its avid binding to mitochondrial… CONTINUE READING
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