Bid antisense attenuates bile acid-induced apoptosis and cholestatic liver injury.

  title={Bid antisense attenuates bile acid-induced apoptosis and cholestatic liver injury.},
  author={Hajime Higuchi and H. Miyoshi and Steven F. Bronk and Hongbing Zhang and Nicholas M. Dean and Gregory J. Gores},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={299 3},
Bile acids cause liver injury during cholestasis by inducing hepatocyte apoptosis by both Fas-dependent and -independent mechanisms. However, the Fas-independent apoptosis also appears to be death receptor-mediated. Because death receptor-mediated apoptosis in hepatocytes requires proapoptotic Bcl-2 BH3 domain only protein Bid, we postulated that Fas-independent but death receptor-mediated bile acid cytotoxicity would be Bid-dependent. We used Fas-deficient lymphoproliferative (lpr) mouse… CONTINUE READING


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