Bicyclol upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia

@article{Zhang2014BicyclolUT,
  title={Bicyclol upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia},
  author={Jian Zhang and Baosheng Fu and Xiangjian Zhang and Lan-tong Zhang and Xue Bai and Xumeng Zhao and Linyu Chen and Li-li Cui and Chunhua Zhu and Lina Wang and Yuan-Yu Zhao and Ting Zhao and Xiaolu Wang},
  journal={Brain Research Bulletin},
  year={2014},
  volume={100},
  pages={38-43}
}
UNLABELLED Oxidative damage plays a detrimental role in the pathophysiology of cerebral ischemia and may represent a therapeutic target. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) controls the coordinated expression of the important antioxidant and detoxification genes through a promotor sequence termed the antioxidant response element. Bicyclol has been proved to elicit a variety of biological effects through its antioxidant and anti-inflammatory properties… Expand
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References

SHOWING 1-10 OF 25 REFERENCES
Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia
TLDR
Curcumin protected the brain from damage caused by MCAO, this effect may be through upregulation of the transcription factor Nrf2 expression. Expand
Neuroprotective effect of bicyclol in rat ischemic stroke: Down-regulates TLR4, TLR9, TRAF6, NF-κB, MMP-9 and up-regulates claudin-5 expression
TLDR
Bicyclol has neuroprotective effect on cerebral ischemia, and this protection may be through down- Regulating TLR4, TLR9, TRAF6, NF-κB, MMP-9 and up-regulating claudin-5 expression. Expand
A Small-Molecule-Inducible Nrf2-Mediated Antioxidant Response Provides Effective Prophylaxis against Cerebral Ischemia In Vivo
TLDR
It is reported that Nrf2 activation protects the brain from cerebral ischemia in vivo and plays a role in modulating ischemic injury in vivo, and NRF2 activation by small molecule inducers may be a practical preventative treatment for stroke-prone patients. Expand
Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice
TLDR
It is demonstrated that ursolic acid (UA), a natural pentacyclic triterpenoid acid, isolated from edible plants in the Oleaceae family, a well-known anti-oxidative and anti-inflammatory reagent, protects the brain against ischemic injury by activating the Nrf2 pathway. Expand
The protection by Octreotide against experimental ischemic stroke: Up-regulated transcription factor Nrf2, HO-1 and down-regulated NF-κB expression
TLDR
OCT protected the brain against cerebral ischemic damage; this effect may be through upregulation of transcription factor Nrf2, HO-1 and downregulation of NF-κB expression. Expand
Polydatin modulates inflammation by decreasing NF-κB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood–brain barrier permeability for its neuroprotective effect in pMCAO rat brain
TLDR
The results indicated that polydatin protected the brain from damage caused by pMCAO, and this effect may be through up- Regulating the expression of Gli1, Ptch1 and SOD1 and down-regulating theexpression of NF-κB, and ameliorating BBB permeability. Expand
The neuroprotection of oxymatrine in cerebral ischemia/reperfusion is related to nuclear factor erythroid 2-related factor 2 (nrf2)-mediated antioxidant response: role of nrf2 and hemeoxygenase-1 expression.
TLDR
The results suggest that oxymatrine administered systemically protected brain against focal ischemia-reperfusion damage at the early stage of stroke, and that activating Nrf2/HO-1 pathway may contribute to the neuroprotective action of oxym atrine in rat focal brain ischemIA-rePerfusion model. Expand
Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury
TLDR
It is suggested that Nrf2 reduces ischemic brain injury by protecting against oxidative stress by reducing ischemia/reperfusion injury. Expand
Bicyclol attenuates oxidative stress and neuronal damage following transient forebrain ischemia in mouse cortex and hippocampus
TLDR
It is suggested that bicyclol protects the mouse brain against cerebral IR injury by attenuating oxidative stress and lipid peroxidation. Expand
Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers.
  • T. Satoh, S. Okamoto, +5 authors S. Lipton
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006
TLDR
The results suggest that NEPPs prevent excitotoxicity by activating the Keap1/Nrf2/HO-1 pathway, and may provide a category of neuroprotective compounds, distinct from other electrophilic compounds such as tert-butylhydroquinone, which activates the antioxidant-responsive element in astrocytes. Expand
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