Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56lck.

@article{Burke1993BicyclicCA,
  title={Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56lck.},
  author={T. Burke and B. Lim and V. Marquez and Z. Li and J. Bolen and I. {\vS}tefanov{\'a} and I. Horak},
  journal={Journal of medicinal chemistry},
  year={1993},
  volume={36 4},
  pages={
          425-32
        }
}
A study was undertaken to prepare inhibitors of the lymphocyte protein-tyrosine kinase p56lck. Using the known p56lck inhibitor 3,4-dihydroxy-alpha-cyanocinnamamide (4) as a lead compound, bicyclic analogues were designed as conformationally constrained mimetics in which the phenyl ring and vinyl side chain of the cinnamamide are locked into a coplanar orientation. Such planarity was rationalized to be an important determinant for binding within a putative flat, cleftlike catalytic cavity… Expand
Cell protein cross-linking by erbstatin and related compounds.
Protein kinase inhibitors: the tyrosine-specific protein kinases.
Peptide inhibitors of protein kinases-discovery, characterisation and use.
...
1
2
3
4
5
...