Bicuculline and Inhibition of Crayfish Stretch Receptor Neurones

  title={Bicuculline and Inhibition of Crayfish Stretch Receptor Neurones},
  author={H. Mclennan},
THE recent reports1,2 on the antagonistic effect of the alkaloid bicuculline both of the actions of γ-aminobutyric acid (GABA) electrophoretically applied to single neurones and of certain strychnine-resistant inhibitory mechanisms in the mammalian central nervous system have suggested that the effects of this substance should be examined in crustacea where GABA is likely to act as a transmitter of post-synaptic inhibition3. 

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