Bicellar systems to modify the phase behaviour of skin stratum corneum lipids.

@article{Rodrguez2012BicellarST,
  title={Bicellar systems to modify the phase behaviour of skin stratum corneum lipids.},
  author={Gelen Rodr{\'i}guez and Mercedes Cocera and Laia Rubio and Cristina Alonso and Ramon Pons and Christophe Sandt and Paul Dumas and Carmen López-Iglesias and Alfons de la Maza and Olga L{\'o}pez},
  journal={Physical chemistry chemical physics : PCCP},
  year={2012},
  volume={14 42},
  pages={
          14523-33
        }
}
Bicellar systems are a fascinating category of versatile lipid assemblies that comprise bilayered disk-shaped nanoaggregates formed in water by long and short alkyl chain phospholipids. Bicelles bridge the gap between micelles and lipid vesicles by combining the attractive properties of both systems. These structures have recently been proposed in dermatological, cosmetic and pharmaceutical applications. Two new binary bicellar systems composed of cholesterol sulphate (SCHOL) and long-chain… Expand
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References

SHOWING 1-10 OF 51 REFERENCES
Effect of bicellar systems on skin properties.
TLDR
The results show that bicelles increase the TEWL, the skin elastic parameters and, decrease skin hydration without promoting local signs of irritation and without affecting the SC lipid microstructure. Expand
A unique bicellar nanosystem combining two effects on stratum corneum lipids.
TLDR
This work compares for the first time the use of two different X-ray scattering methods, transmission with synchrotron radiation and grazing incidence with conventional source, for skin studies and indicates that vesicle-shaped structures remain adhered to the SC surface being unable to penetrate into the skin probably due to their large and voluminous size. Expand
Application of bicellar systems on skin: diffusion and molecular organization effects.
TLDR
Analysis of the lipid organization in terms of chain conformational order and lateral packing shows that the use of bicelles hampers the fluidification of SC lipids with temperature and leads to a lateral packing corresponding to a stable hexagonal phase. Expand
Penetration and growth of DPPC/DHPC bicelles inside the stratum corneum of the skin.
TLDR
The bicellar system used is suitable to penetrate the skin SC and to reinforce the intercellular lipid areas, constituting a promising tool for skin applications. Expand
Lipid nanostructures: self-assembly and effect on skin properties.
TLDR
The results revealed that nanostructures with similar assembly but different composition caused different effects on the skin parameters, and samples containing DMPC affected the barrier function to a greater extent than systems containing DPPC. Expand
Conformational changes in stratum corneum lipids by effect of bicellar systems.
TLDR
Bicellar systems caused a phase transition from the gel or solid state to the liquid crystalline state in the lipid conformation of SC, reflecting the major order-disorder transition from hexagonally packed to disordered chains. Expand
Direct visualization of lipid domains in human skin stratum corneum's lipid membranes: effect of pH and temperature.
TLDR
Hydrated bilayers of human skin stratum corneum lipids express a giant sponge-like morphology with dimensions corresponding to the global three-dimensional morphology of the stratum Corneum extracellular space, suggesting that the local pH in the strum corneum may control the physical properties of theextracellular lipid matrix by regulating membrane lateral structure and stability. Expand
The Effect of Liposomes on Skin Barrier Structure
TLDR
‘In vivo’ stripping technique to evaluate the percutaneous absorption of sodium fluorescein (NaFl) vehiculized in two different liposome preparations formed by phosphatidylcholine and lipids mimicking the stratum corneum suggests a greater reservoir capacity of SC when similar lipid composition formulation is applied. Expand
Bicelles: lipid nanostructured platforms with potential dermal applications.
TLDR
The remarkable versatility of bicelles is their most important characteristic, which makes their use possible in various fields, and this system represents a platform for dermal applications. Expand
Different stratum corneum lipid liposomes as models to evaluate the effect of the sodium dodecyl sulfate.
TLDR
The stability of stratum corneum (SC) liposomes against the action of surfactants has been revised and it is noteworthy that the surfactant partitioning between bilayers and the aqueous phase increased and decreased, respectively, as the proportion of Cer and Chol-sulf increased. Expand
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